If you have a 330 cylinder on the engine now & running it, your cases have the right size bore & will be the right size bore even if you go to a 350 Pro-x cylinder.
On all of the Pro-x cylinders, & ESR cylinders, the skirt part of the sleeve that fits down into the cases, all of them are machined to fit down into that 3.350 machined out opening of the 250R cases.
Only other thing, like if the 330 cylinder is one of the bolt on type, then one of those cylinders the skirt is only like 5mm long, so the spacer plate provides the clearance needed to bolt the cylinder down onto the cases & no machining of the cases is needed, because the skirt will no go down into the cases.
It is fairly easy, to see if the cases have been machined or if the cylinder is the bolt on type, simply pull the carb & reed cage & with a light, look down into the cylinder & you can see over to the other side of the cases & cylinder skirt & can tell right off what you got. Not that hard to do even with the engine still in the frame. I've done it many times, even with my big head.
Neil